MRPS33 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= MRPS33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS33
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51650|51650]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y291|Q9Y291]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611993|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S33|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-2.44|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.4|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.19|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.18|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.03|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.01|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.01|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.98|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.92|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.87|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.77|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.75|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.72|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.71|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.76|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.76|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.79|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.84|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.04|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.07|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.17|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.21|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.24|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.41|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.622|
|[[:human genes:m:mrps6|MRPS6]]|0.597|
|[[:human genes:y:yars2|YARS2]]|0.59|
|[[:human genes:n:ndufa3|NDUFA3]]|0.584|
|[[:human genes:g:gfm1|GFM1]]|0.583|
|[[:human genes:d:dars2|DARS2]]|0.583|
|[[:human genes:m:mrps21|MRPS21]]|0.578|
|[[:human genes:m:mrps14|MRPS14]]|0.575|
|[[:human genes:m:mrps5|MRPS5]]|0.574|
|[[:human genes:t:tefm|TEFM]]|0.569|
|[[:human genes:m:mrpl53|MRPL53]]|0.559|
|[[:human genes:m:mrps16|MRPS16]]|0.559|
|[[:human genes:m:mrpl15|MRPL15]]|0.559|
|[[:human genes:n:ndufb11|NDUFB11]]|0.555|
|[[:human genes:t:tufm|TUFM]]|0.552|
|[[:human genes:m:mrpl21|MRPL21]]|0.549|
|[[:human genes:t:tars2|TARS2]]|0.548|
|[[:human genes:m:mrpl23|MRPL23]]|0.547|
|[[:human genes:p:pars2|PARS2]]|0.54|
|[[:human genes:s:sars2|SARS2]]|0.54|
|[[:human genes:m:mrp63|MRP63]]|0.536|
|[[:human genes:m:mrps26|MRPS26]]|0.532|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.531|
|[[:human genes:d:dap3|DAP3]]|0.531|
|[[:human genes:e:elac2|ELAC2]]|0.53|
|[[:human genes:m:mrps34|MRPS34]]|0.524|
|[[:human genes:l:lars2|LARS2]]|0.52|
|[[:human genes:q:qrsl1|QRSL1]]|0.52|
|[[:human genes:m:mrps2|MRPS2]]|0.519|
|[[:human genes:n:ndufb5|NDUFB5]]|0.519|
|[[:human genes:e:ears2|EARS2]]|0.518|
|[[:human genes:c:c10orf2|C10orf2]]|0.517|
|[[:human genes:a:atp5sl|ATP5SL]]|0.517|
|[[:human genes:s:slc25a26|SLC25A26]]|0.514|
|[[:human genes:p:ppa2|PPA2]]|0.513|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.512|
|[[:human genes:s:selrc1|SELRC1]]|0.511|
|[[:human genes:n:nars2|NARS2]]|0.511|
|[[:human genes:v:vars2|VARS2]]|0.511|
|[[:human genes:n:ndufa1|NDUFA1]]|0.51|
|[[:human genes:w:wbscr16|WBSCR16]]|0.509|
|[[:human genes:s:sco2|SCO2]]|0.507|
|[[:human genes:h:hars2|HARS2]]|0.506|
|[[:human genes:c:c12orf65|C12orf65]]|0.506|
|[[:human genes:r:rpusd4|RPUSD4]]|0.505|
|[[:human genes:c:cox17|COX17]]|0.504|
|[[:human genes:n:ndufc2|NDUFC2]]|0.503|
|[[:human genes:p:pnpt1|PNPT1]]|0.502|
|[[:human genes:n:ndufa2|NDUFA2]]|0.502|
|[[:human genes:g:gatc|GATC]]|0.5|
|[[:human genes:b:bcs1l|BCS1L]]|0.497|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.496|
|[[:human genes:c:chchd4|CHCHD4]]|0.496|
|[[:human genes:m:mrps9|MRPS9]]|0.496|
|[[:human genes:m:mars2|MARS2]]|0.488|
|[[:human genes:p:polg|POLG]]|0.488|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.488|
|[[:human genes:m:mrps18a|MRPS18A]]|0.486|
|[[:human genes:m:mrpl45|MRPL45]]|0.485|
|[[:human genes:r:rbfa|RBFA]]|0.485|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.485|
|[[:human genes:r:rpia|RPIA]]|0.484|
|[[:human genes:d:dpagt1|DPAGT1]]|0.482|
|[[:human genes:m:mrps25|MRPS25]]|0.481|
|[[:human genes:g:gfm2|GFM2]]|0.481|
|[[:human genes:f:fastkd5|FASTKD5]]|0.481|
|[[:human genes:c:c17orf89|C17orf89]]|0.48|
|[[:human genes:a:atxn10|ATXN10]]|0.479|
|[[:human genes:m:mrpl3|MRPL3]]|0.479|
|[[:human genes:n:ndufb6|NDUFB6]]|0.478|
|[[:human genes:u:uhrf1|UHRF1]]|0.476|
|[[:human genes:p:pmm2|PMM2]]|0.473|
|[[:human genes:f:ftsj2|FTSJ2]]|0.472|
|[[:human genes:t:triap1|TRIAP1]]|0.471|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.47|
|[[:human genes:m:mrpl44|MRPL44]]|0.47|
|[[:human genes:p:pdss1|PDSS1]]|0.469|
|[[:human genes:c:cox16|COX16]]|0.469|
|[[:human genes:t:tfam|TFAM]]|0.468|
|[[:human genes:a:alg1|ALG1]]|0.468|
|[[:human genes:m:mtg2|MTG2]]|0.465|
|[[:human genes:m:mrpl47|MRPL47]]|0.463|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.461|
|[[:human genes:d:dhrsx|DHRSX]]|0.461|
|[[:human genes:a:atp5c1|ATP5C1]]|0.46|
|[[:human genes:t:tomm22|TOMM22]]|0.46|
|[[:human genes:m:mrps24|MRPS24]]|0.459|
|[[:human genes:r:rfk|RFK]]|0.458|
|[[:human genes:m:mrps11|MRPS11]]|0.457|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.457|
|[[:human genes:a:atp5j|ATP5J]]|0.455|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.453|
|[[:human genes:d:dolk|DOLK]]|0.452|
|[[:human genes:a:alg6|ALG6]]|0.451|
|[[:human genes:a:alg5|ALG5]]|0.451|
|[[:human genes:t:tomm20|TOMM20]]|0.449|
|[[:human genes:n:ndufa11|NDUFA11]]|0.448|
|[[:human genes:f:fars2|FARS2]]|0.447|
|[[:human genes:r:rars2|RARS2]]|0.447|
|[[:human genes:p:pggt1b|PGGT1B]]|0.447|
|[[:human genes:m:mrpl42|MRPL42]]|0.446|
|[[:human genes:e:eny2|ENY2]]|0.446|
|[[:human genes:v:vezt|VEZT]]|0.446|
|[[:human genes:m:mrps17|MRPS17]]|0.445|
|[[:human genes:p:pet112|PET112]]|0.445|
|[[:human genes:e:ecsit|ECSIT]]|0.444|
|[[:human genes:u:uqcr10|UQCR10]]|0.443|
|[[:human genes:o:opa1|OPA1]]|0.443|
|[[:human genes:p:pet100|PET100]]|0.443|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.442|
|[[:human genes:a:atp5h|ATP5H]]|0.441|
|[[:human genes:s:srd5a3|SRD5A3]]|0.44|
|[[:human genes:c:crls1|CRLS1]]|0.439|
|[[:human genes:n:ndufs2|NDUFS2]]|0.438|
|[[:human genes:t:tpk1|TPK1]]|0.438|
|[[:human genes:r:rpusd3|RPUSD3]]|0.438|
|[[:human genes:p:polg2|POLG2]]|0.436|
|[[:human genes:m:mrpl12|MRPL12]]|0.435|
|[[:human genes:s:srp14|SRP14]]|0.435|
|[[:human genes:f:fh|FH]]|0.435|
|[[:human genes:a:aifm1|AIFM1]]|0.435|
|[[:human genes:m:mtg1|MTG1]]|0.434|
|[[:human genes:n:ndufa10|NDUFA10]]|0.433|
|[[:human genes:n:nfu1|NFU1]]|0.433|
|[[:human genes:a:atp5a1|ATP5A1]]|0.431|
|[[:human genes:t:tmem261|TMEM261]]|0.43|
|[[:human genes:a:atp5d|ATP5D]]|0.43|
|[[:human genes:c:coa6|COA6]]|0.429|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.429|
|[[:human genes:a:atp5b|ATP5B]]|0.429|
|[[:human genes:t:thg1l|THG1L]]|0.428|
|[[:human genes:n:ndufs7|NDUFS7]]|0.428|
|[[:human genes:s:slc25a19|SLC25A19]]|0.427|
|[[:human genes:m:mrpl20|MRPL20]]|0.427|
|[[:human genes:m:mrps12|MRPS12]]|0.426|
|[[:human genes:m:mrps23|MRPS23]]|0.426|
|[[:human genes:m:mettl17|METTL17]]|0.426|
|[[:human genes:n:ndufb9|NDUFB9]]|0.424|
|[[:human genes:c:chchd1|CHCHD1]]|0.424|
|[[:human genes:m:mrps7|MRPS7]]|0.42|
|[[:human genes:c:coq5|COQ5]]|0.418|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.417|
|[[:human genes:p:ppcs|PPCS]]|0.417|
|[[:human genes:g:glrx5|GLRX5]]|0.414|
|[[:human genes:m:mbtps2|MBTPS2]]|0.412|
|[[:human genes:t:timm8b|TIMM8B]]|0.411|
|[[:human genes:m:mrpl43|MRPL43]]|0.411|
|[[:human genes:m:mrps28|MRPS28]]|0.41|
|[[:human genes:n:ndufb3|NDUFB3]]|0.41|
|[[:human genes:g:gmppb|GMPPB]]|0.41|
|[[:human genes:l:lsm10|LSM10]]|0.408|
|[[:human genes:a:acad9|ACAD9]]|0.408|
|[[:human genes:m:mipep|MIPEP]]|0.407|
|[[:human genes:c:cox19|COX19]]|0.407|
|[[:human genes:g:grsf1|GRSF1]]|0.406|
|[[:human genes:c:cox6c|COX6C]]|0.406|
|[[:human genes:c:cox7b|COX7B]]|0.405|
|[[:human genes:t:tomm40|TOMM40]]|0.403|
|[[:human genes:m:mrps10|MRPS10]]|0.403|
|[[:human genes:m:mrpl34|MRPL34]]|0.402|
|[[:human genes:a:alg8|ALG8]]|0.402|
|[[:human genes:i:iba57|IBA57]]|0.401|
|[[:human genes:c:cars2|CARS2]]|0.401|
|[[:human genes:m:mrpl11|MRPL11]]|0.4|
|[[:human genes:c:cbfb|CBFB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS33 Expression in NALM6 Cells: 4.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>