MRPS33

Gene Information

Official Symbol: MRPS33
Official Name: mitochondrial ribosomal protein S33
Aliases and Previous Symbols: N/A
Entrez ID: 51650
UniProt: Q9Y291
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BRD2 inhibitor II 20μM R07 exp341	-2.44
Lead acetate 990μM R08 exp496	-2.4
Parthenolide 2.5μM R05 exp238	-2.19
IU1-C 25μM R04 exp183	-2.18
Lenalidomide 20μM R07 exp375	-2.03
Benzoate 10000μM R08 exp455	-2.01
Dimethyloxaloylglycine 11μM R07 exp314	-2.01
proTAME 5μM R04 exp187	-1.98
Colchicine 0.009μM R05 exp215	-1.92
Metformin 100 to 150μM on day4 R04 exp170	-1.87
CCCP 0.1μM R00 exp10	-1.77
A-769662 20μM R07 exp331	-1.75
PF-06409577 20μM R07 exp389	-1.72
ETC-159 50μM R08 exp480	-1.7
Ammonium tetrathiomolybdate 10μM R08 exp448	1.71
CI-1040 9.5μM R08 exp472	1.72
Atovaquone 15μM R08 exp451	1.76
PU-H71 1μM R08 exp515	1.76
I-BRD9 4μM R07 exp365	1.79
Thimerosal 0.85μM R08 exp529	1.81
Palbociclib 1μM R07 exp382	1.84
Tanespimycin 14μM R08 exp527	2.04
Oligomycin-A 2μM R00 exp25	2.07
Brefeldin A 0.02μM R00 exp8	2.17
TIC10 10μM R08 exp532	2.21
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.24
Monensin 0.3μM R08 exp507	2.41
ONC212 0.15μM R08 exp513	2.86
Mitomycin-C 0.06μM R08 exp503	3.12

Gene	Correlation
HSD17B10	0.622
MRPS6	0.597
YARS2	0.59
NDUFA3	0.584
GFM1	0.583
DARS2	0.583
MRPS21	0.578
MRPS14	0.575
MRPS5	0.574
TEFM	0.569
MRPL53	0.559
MRPS16	0.559
MRPL15	0.559
NDUFB11	0.555
TUFM	0.552
MRPL21	0.549
TARS2	0.548
MRPL23	0.547
PARS2	0.54
SARS2	0.54
MRP63	0.536
MRPS26	0.532
SUPV3L1	0.531
DAP3	0.531
ELAC2	0.53
MRPS34	0.524
LARS2	0.52
QRSL1	0.52
MRPS2	0.519
NDUFB5	0.519
EARS2	0.518
C10orf2	0.517
ATP5SL	0.517
SLC25A26	0.514
PPA2	0.513
KIAA0391	0.512
SELRC1	0.511
NARS2	0.511
VARS2	0.511
NDUFA1	0.51
WBSCR16	0.509
SCO2	0.507
HARS2	0.506
C12orf65	0.506
RPUSD4	0.505
COX17	0.504
NDUFC2	0.503
PNPT1	0.502
NDUFA2	0.502
GATC	0.5
BCS1L	0.497
NDUFAF7	0.496
CHCHD4	0.496
MRPS9	0.496
MARS2	0.488
POLG	0.488
NDUFAF4	0.488
MRPS18A	0.486
MRPL45	0.485
RBFA	0.485
AASDHPPT	0.485
RPIA	0.484
DPAGT1	0.482
MRPS25	0.481
GFM2	0.481
FASTKD5	0.481
C17orf89	0.48
ATXN10	0.479
MRPL3	0.479
NDUFB6	0.478
UHRF1	0.476
PMM2	0.473
FTSJ2	0.472
TRIAP1	0.471
MTRF1L	0.47
MRPL44	0.47
PDSS1	0.469
COX16	0.469
TFAM	0.468
ALG1	0.468
MTG2	0.465
MRPL47	0.463
GTPBP10	0.461
DHRSX	0.461
ATP5C1	0.46
TOMM22	0.46
MRPS24	0.459
RFK	0.458
MRPS11	0.457
RNASEH1	0.457
ATP5J	0.455
RTN4IP1	0.453
DOLK	0.452
ALG6	0.451
ALG5	0.451
TOMM20	0.449
NDUFA11	0.448
FARS2	0.447
RARS2	0.447
PGGT1B	0.447
MRPL42	0.446
ENY2	0.446
VEZT	0.446
MRPS17	0.445
PET112	0.445
ECSIT	0.444
UQCR10	0.443
OPA1	0.443
PET100	0.443
NDUFAF3	0.442
ATP5H	0.441
SRD5A3	0.44
CRLS1	0.439
NDUFS2	0.438
TPK1	0.438
RPUSD3	0.438
POLG2	0.436
MRPL12	0.435
SRP14	0.435
FH	0.435
AIFM1	0.435
MTG1	0.434
NDUFA10	0.433
NFU1	0.433
ATP5A1	0.431
TMEM261	0.43
ATP5D	0.43
COA6	0.429
RNMTL1	0.429
ATP5B	0.429
THG1L	0.428
NDUFS7	0.428
SLC25A19	0.427
MRPL20	0.427
MRPS12	0.426
MRPS23	0.426
METTL17	0.426
NDUFB9	0.424
CHCHD1	0.424
MRPS7	0.42
COQ5	0.418
GTF3C6	0.417
PPCS	0.417
GLRX5	0.414
MBTPS2	0.412
TIMM8B	0.411
MRPL43	0.411
MRPS28	0.41
NDUFB3	0.41
GMPPB	0.41
LSM10	0.408
ACAD9	0.408
MIPEP	0.407
COX19	0.407
GRSF1	0.406
COX6C	0.406
COX7B	0.405
TOMM40	0.403
MRPS10	0.403
MRPL34	0.402
ALG8	0.402
IBA57	0.401
CARS2	0.401
MRPL11	0.4
CBFB	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3008
Expression level (log2 read counts): 4.33

Expression Distribution

mitochondrial small ribosomal subunit
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression