MRS2 [The Human Chemical-Genetic Interaction Map Project]

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======= MRS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRS2
  * **<color #00a2e8>Official Name</color>**: magnesium transporter MRS2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57380|57380]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HD23|Q9HD23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619307|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665). {ECO:0000269|PubMed:11401429, ECO:0000269|PubMed:18384665}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial magnesium ion transmembrane transport|
|lactate metabolic process|
|magnesium ion transmembrane transport|
|magnesium ion transmembrane transporter activity|
|magnesium ion transport|
|mitochondrial transmembrane transport|
|mitochondrial transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|mitochondrial inner membrane|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cation transport|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|transmembrane transport|
|ion transport|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.36|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.34|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.16|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.15|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.14|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.14|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.13|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.12|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.12|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.98|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.9|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.89|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.73|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.7|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.72|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.73|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.95|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox7a2l|COX7A2L]]|0.622|
|[[:human genes:s:slc25a36|SLC25A36]]|0.543|
|[[:human genes:p:polr2j3|POLR2J3]]|0.509|
|[[:human genes:r:rpl35|RPL35]]|0.446|
|[[:human genes:s:slc25a33|SLC25A33]]|0.435|
|[[:human genes:t:taf1|TAF1]]|0.426|
|[[:human genes:n:nfatc4|NFATC4]]|0.414|
|[[:human genes:m:mgme1|MGME1]]|0.408|
|[[:human genes:m:myb|MYB]]|0.405|
|[[:human genes:p:prpf3|PRPF3]]|0.404|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRS2 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>