MRS2

Entrez Summary: N/A
UniProt Summary: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665). {ECO:0000269|PubMed:11401429, ECO:0000269|PubMed:18384665}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial magnesium ion transmembrane transport
lactate metabolic process
magnesium ion transmembrane transport
magnesium ion transmembrane transporter activity
magnesium ion transport
mitochondrial transmembrane transport
mitochondrial transport
divalent metal ion transport
divalent inorganic cation transport
mitochondrial inner membrane
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cation transport
carboxylic acid metabolic process
ion transmembrane transport
oxoacid metabolic process
organic acid metabolic process
mitochondrion
transmembrane transport
ion transport
small molecule metabolic process