MS4A1

Entrez Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008].
UniProt Summary: This protein may be involved in the regulation of B-cell activation and proliferation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

immunoglobulin binding
store-operated calcium entry
calcium ion import into cytosol
MHC class II protein complex binding
plasma membrane raft
epidermal growth factor receptor binding
B cell proliferation
calcium ion import
calcium ion transport into cytosol
lymphocyte proliferation
mononuclear cell proliferation
cytosolic calcium ion transport
leukocyte proliferation
B cell differentiation
B cell receptor signaling pathway
protein tetramerization
B cell activation
lymphocyte differentiation
calcium ion transport
positive regulation of cytosolic calcium ion concentration
antigen receptor-mediated signaling pathway
divalent metal ion transport
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration
leukocyte differentiation
humoral immune response
lymphocyte activation
external side of plasma membrane
cellular calcium ion homeostasis
immune response-activating cell surface receptor signaling pathway
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
immune response-regulating cell surface receptor signaling pathway
divalent inorganic cation homeostasis
protein complex oligomerization
cell population proliferation
cellular metal ion homeostasis
hemopoiesis
immune response-activating signal transduction
immune response-regulating signaling pathway