MSH4 [The Human Chemical-Genetic Interaction Map Project]

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======= MSH4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSH4
  * **<color #00a2e8>Official Name</color>**: mutS homolog 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4438|4438]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15457|O15457]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSH4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSH4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602105|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MutS III|
|MutS II|
|MutS IV|
|MutS V|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|recombination nodule|
|mismatched DNA binding|
|mismatch repair complex|
|resolution of meiotic recombination intermediates|
|meiotic chromosome separation|
|synaptonemal complex|
|nuclear chromosome|
|chromosome separation|
|mismatch repair|
|DNA-dependent ATPase activity|
|synapsis|
|reciprocal meiotic recombination|
|ovarian follicle development|
|homologous recombination|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|female gonad development|
|meiotic chromosome segregation|
|development of primary female sexual characteristics|
|female sex differentiation|
|meiosis I|
|meiosis I cell cycle process|
|female gamete generation|
|meiotic nuclear division|
|meiotic cell cycle process|
|gonad development|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|sex differentiation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|reproductive structure development|
|reproductive system development|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|ATP binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSH4 Expression in NALM6 Cells: -0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>