MSH4

Entrez Summary: This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011].
UniProt Summary: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

recombination nodule
mismatched DNA binding
mismatch repair complex
resolution of meiotic recombination intermediates
meiotic chromosome separation
synaptonemal complex
nuclear chromosome
chromosome separation
mismatch repair
DNA-dependent ATPase activity
synapsis
reciprocal meiotic recombination
ovarian follicle development
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
female gonad development
meiotic chromosome segregation
development of primary female sexual characteristics
female sex differentiation
meiosis I
meiosis I cell cycle process
female gamete generation
meiotic nuclear division
meiotic cell cycle process
gonad development
development of primary sexual characteristics
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
sex differentiation
chromosome segregation
nuclear division
organelle fission
reproductive structure development
reproductive system development
DNA repair
spermatogenesis
male gamete generation
developmental process involved in reproduction