MT2A

Entrez Summary: N/A
UniProt Summary: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

cellular response to erythropoietin
response to erythropoietin
response to interleukin-3
cellular response to interleukin-3
cellular copper ion homeostasis
stress response to copper ion
detoxification of copper ion
copper ion homeostasis
detoxification of inorganic compound
stress response to metal ion
nitric oxide mediated signal transduction
cellular response to zinc ion
cellular response to copper ion
cellular zinc ion homeostasis
zinc ion homeostasis
cellular response to cadmium ion
response to copper ion
response to zinc ion
drug binding
response to cadmium ion
interferon-gamma-mediated signaling pathway
cellular transition metal ion homeostasis
detoxification
transition metal ion homeostasis
cellular response to interferon-gamma
response to interferon-gamma
cellular response to metal ion
cellular response to inorganic substance
negative regulation of growth
second-messenger-mediated signaling
response to metal ion
cellular response to drug
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
response to toxic substance
response to inorganic substance
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis