MTBP [The Human Chemical-Genetic Interaction Map Project]

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======= MTBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTBP
  * **<color #00a2e8>Official Name</color>**: MDM2 binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27085|27085]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DY7|Q96DY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605927|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|traversing start control point of mitotic cell cycle|
|protein localization to kinetochore|
|protein localization to chromosome, centromeric region|
|positive regulation of G1/S transition of mitotic cell cycle|
|negative regulation of mitotic nuclear division|
|positive regulation of cell cycle G1/S phase transition|
|negative regulation of nuclear division|
|protein localization to chromosome|
|positive regulation of mitotic cell cycle phase transition|
|kinetochore|
|positive regulation of cell cycle phase transition|
|chromatin|
|cell cycle arrest|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|negative regulation of cell population proliferation|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.84|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.78|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.75|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.7|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.74|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.78|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.79|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 736/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2000
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTBP Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>