MTBP

Gene Information

Official Symbol: MTBP
Official Name: MDM2 binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 27085
UniProt: Q96DY7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012].
UniProt Summary: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DABN racemic mixture R03 exp93	-1.84
Genistein 15μM R07 exp360	-1.78
Nocodazole 0.1μM R03 exp94	-1.75
MS094 2μM R03 exp136	1.7
Cadmium 60μM R08 exp462	1.74
OICR-9429 10μM R03 exp142	1.78
Q15 1 to 2μM on day4 R04 exp164	1.79
Dimethyl-Sulfoxide 1pc R03 exp120	2.1

Global Fraction of Cell Lines Where Essential: 736/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	26/26
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 2000
Expression level (log2 read counts): 5.23

Expression Distribution

traversing start control point of mitotic cell cycle
protein localization to kinetochore
protein localization to chromosome, centromeric region
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of mitotic nuclear division
positive regulation of cell cycle G1/S phase transition
negative regulation of nuclear division
protein localization to chromosome
positive regulation of mitotic cell cycle phase transition
kinetochore
positive regulation of cell cycle phase transition
chromatin
cell cycle arrest
regulation of G1/S transition of mitotic cell cycle
positive regulation of mitotic cell cycle
regulation of cell cycle G1/S phase transition
regulation of mitotic nuclear division
regulation of nuclear division
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
positive regulation of cell cycle process
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
negative regulation of organelle organization
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
negative regulation of cell cycle
regulation of mitotic cell cycle
negative regulation of cell population proliferation
negative regulation of cellular component organization
protein localization to organelle
regulation of cell cycle process
cell cycle process
regulation of cell cycle
regulation of organelle organization
cell cycle
cellular protein localization
cellular macromolecule localization
regulation of cell population proliferation