MTERF [The Human Chemical-Genetic Interaction Map Project]

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======= MTERF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTERF1
  * **<color #00a2e8>Official Name</color>**: mitochondrial transcription termination factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7978|7978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99551|Q99551]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTERF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTERF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602318|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. {ECO:0000269|PubMed:20550934}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|mTERF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|termination of mitochondrial transcription|
|mitochondrial transcription|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|DNA-templated transcription, termination|
|double-stranded DNA binding|
|DNA geometric change|
|mitochondrial gene expression|
|DNA conformation change|
|mitochondrial matrix|
|mitochondrion organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.24|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.75|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.76|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.77|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.84|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.9|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.97|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.05|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.13|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.22|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTERF Expression in NALM6 Cells: 2.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>