MTERF

Entrez Summary: N/A
UniProt Summary: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. {ECO:0000269|PubMed:20550934}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Citral 50μM R06 exp274	-2.24
Hydroxyurea 100μM R07 exp329	1.75
Nocodazole 0.02μM R00 exp23	1.76
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.77
Rotenone 20μM R00 exp34	1.84
THZ531 0.11μM R07 exp409	1.9
PFI-3 10μM R03 exp144	1.97
HMS-I2 5μM R06 exp287	2.05
Tubastatin-A 2.5μM R07 exp417	2.13
UM131593 0.1μM R01 exp58	2.22
FTY720 3μM R08 exp483	2.39

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

termination of mitochondrial transcription
mitochondrial transcription
mitochondrial RNA metabolic process
mitochondrial nucleoid
DNA-templated transcription, termination
double-stranded DNA binding
DNA geometric change
mitochondrial gene expression
DNA conformation change
mitochondrial matrix
mitochondrion organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
RNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression