MTERFD2 [The Human Chemical-Genetic Interaction Map Project]

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======= MTERFD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTERF4
  * **<color #00a2e8>Official Name</color>**: mitochondrial transcription termination factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=130916|130916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6M4|Q7Z6M4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTERFD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTERFD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S). {ECO:0000269|PubMed:21531335}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|mTERF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome assembly|
|mitochondrial transcription|
|rRNA methylation|
|rRNA modification|
|rRNA binding|
|mitochondrial RNA metabolic process|
|mitochondrial large ribosomal subunit|
|protein targeting to mitochondrion|
|ribosome assembly|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|RNA methylation|
|double-stranded DNA binding|
|mitochondrial translation|
|mitochondrial gene expression|
|RNA modification|
|rRNA processing|
|mitochondrial transport|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|camera-type eye development|
|protein targeting|
|eye development|
|visual system development|
|sensory system development|
|mitochondrial matrix|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|mitochondrion organization|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|heart development|
|amide biosynthetic process|
|peptide metabolic process|
|sensory organ development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|protein localization to organelle|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|circulatory system development|
|RNA processing|
|intracellular protein transport|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.78|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.571|
|[[:human genes:n:nars2|NARS2]]|0.568|
|[[:human genes:t:tefm|TEFM]]|0.556|
|[[:human genes:f:ftsj2|FTSJ2]]|0.547|
|[[:human genes:q:qrsl1|QRSL1]]|0.542|
|[[:human genes:r:rpusd4|RPUSD4]]|0.542|
|[[:human genes:m:mrps24|MRPS24]]|0.538|
|[[:human genes:m:mrpl53|MRPL53]]|0.538|
|[[:human genes:m:mrpl47|MRPL47]]|0.534|
|[[:human genes:f:fastkd5|FASTKD5]]|0.533|
|[[:human genes:m:mrpl23|MRPL23]]|0.523|
|[[:human genes:m:mrps14|MRPS14]]|0.513|
|[[:human genes:m:mettl17|METTL17]]|0.509|
|[[:human genes:m:mrpl21|MRPL21]]|0.506|
|[[:human genes:m:mrps6|MRPS6]]|0.506|
|[[:human genes:l:lars2|LARS2]]|0.504|
|[[:human genes:s:selrc1|SELRC1]]|0.503|
|[[:human genes:r:rbfa|RBFA]]|0.501|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.499|
|[[:human genes:m:mrps21|MRPS21]]|0.494|
|[[:human genes:t:tars2|TARS2]]|0.493|
|[[:human genes:d:ddx28|DDX28]]|0.492|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.492|
|[[:human genes:p:pars2|PARS2]]|0.492|
|[[:human genes:d:dap3|DAP3]]|0.49|
|[[:human genes:v:vars2|VARS2]]|0.489|
|[[:human genes:m:mrps10|MRPS10]]|0.488|
|[[:human genes:s:sco2|SCO2]]|0.487|
|[[:human genes:m:mrps5|MRPS5]]|0.481|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.48|
|[[:human genes:p:pet112|PET112]]|0.478|
|[[:human genes:g:gatc|GATC]]|0.476|
|[[:human genes:m:mrps12|MRPS12]]|0.474|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.474|
|[[:human genes:m:mrps34|MRPS34]]|0.474|
|[[:human genes:a:aars2|AARS2]]|0.473|
|[[:human genes:m:mtg1|MTG1]]|0.473|
|[[:human genes:c:coa3|COA3]]|0.472|
|[[:human genes:n:ndufb11|NDUFB11]]|0.468|
|[[:human genes:m:mrpl12|MRPL12]]|0.468|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.468|
|[[:human genes:g:gfm2|GFM2]]|0.467|
|[[:human genes:m:mrp63|MRP63]]|0.466|
|[[:human genes:m:mrps16|MRPS16]]|0.466|
|[[:human genes:e:ears2|EARS2]]|0.46|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.46|
|[[:human genes:d:dars2|DARS2]]|0.459|
|[[:human genes:c:chchd1|CHCHD1]]|0.457|
|[[:human genes:m:mrpl44|MRPL44]]|0.457|
|[[:human genes:m:mrps25|MRPS25]]|0.457|
|[[:human genes:m:mrpl15|MRPL15]]|0.457|
|[[:human genes:m:mtg2|MTG2]]|0.455|
|[[:human genes:n:ndufa3|NDUFA3]]|0.453|
|[[:human genes:c:coq2|COQ2]]|0.452|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.451|
|[[:human genes:p:polg|POLG]]|0.451|
|[[:human genes:w:wars2|WARS2]]|0.45|
|[[:human genes:m:mrps18a|MRPS18A]]|0.449|
|[[:human genes:p:polg2|POLG2]]|0.449|
|[[:human genes:m:malsu1|MALSU1]]|0.448|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.448|
|[[:human genes:w:wbscr16|WBSCR16]]|0.447|
|[[:human genes:p:pet117|PET117]]|0.446|
|[[:human genes:m:mrpl4|MRPL4]]|0.446|
|[[:human genes:m:mrps9|MRPS9]]|0.445|
|[[:human genes:m:mrps23|MRPS23]]|0.444|
|[[:human genes:m:mars2|MARS2]]|0.442|
|[[:human genes:t:trub2|TRUB2]]|0.442|
|[[:human genes:g:gfm1|GFM1]]|0.441|
|[[:human genes:m:mtpap|MTPAP]]|0.44|
|[[:human genes:m:mrps27|MRPS27]]|0.439|
|[[:human genes:m:mrpl45|MRPL45]]|0.437|
|[[:human genes:s:sars2|SARS2]]|0.434|
|[[:human genes:m:mrpl55|MRPL55]]|0.434|
|[[:human genes:p:polrmt|POLRMT]]|0.434|
|[[:human genes:n:ndufa2|NDUFA2]]|0.432|
|[[:human genes:p:ptcd3|PTCD3]]|0.43|
|[[:human genes:m:mrps26|MRPS26]]|0.429|
|[[:human genes:a:acad9|ACAD9]]|0.428|
|[[:human genes:r:rars2|RARS2]]|0.427|
|[[:human genes:c:cox16|COX16]]|0.427|
|[[:human genes:b:bcs1l|BCS1L]]|0.426|
|[[:human genes:s:ssbp1|SSBP1]]|0.426|
|[[:human genes:m:mrpl22|MRPL22]]|0.426|
|[[:human genes:f:fastkd2|FASTKD2]]|0.423|
|[[:human genes:m:mrps35|MRPS35]]|0.422|
|[[:human genes:c:c12orf65|C12orf65]]|0.422|
|[[:human genes:h:hars2|HARS2]]|0.421|
|[[:human genes:c:cars2|CARS2]]|0.42|
|[[:human genes:m:mipep|MIPEP]]|0.419|
|[[:human genes:t:tfb1m|TFB1M]]|0.417|
|[[:human genes:l:lrpprc|LRPPRC]]|0.415|
|[[:human genes:m:mrpl1|MRPL1]]|0.415|
|[[:human genes:d:dhx30|DHX30]]|0.414|
|[[:human genes:m:mrps11|MRPS11]]|0.412|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.412|
|[[:human genes:m:mrps17|MRPS17]]|0.411|
|[[:human genes:g:grsf1|GRSF1]]|0.41|
|[[:human genes:n:ndufa1|NDUFA1]]|0.41|
|[[:human genes:n:ndufc2|NDUFC2]]|0.408|
|[[:human genes:n:ndufs2|NDUFS2]]|0.406|
|[[:human genes:m:mrpl41|MRPL41]]|0.405|
|[[:human genes:m:mrps7|MRPS7]]|0.403|
|[[:human genes:c:cox6c|COX6C]]|0.403|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.403|
|[[:human genes:t:tomm20|TOMM20]]|0.401|
|[[:human genes:r:rpusd3|RPUSD3]]|0.401|
|[[:human genes:n:ndufs7|NDUFS7]]|0.401|
|[[:human genes:m:mterfd1|MTERFD1]]|0.4|
|[[:human genes:m:mtif2|MTIF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1733
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTERFD2 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>