MTERFD2

Entrez Summary: N/A
UniProt Summary: Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S). {ECO:0000269|PubMed:21531335}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial ribosome assembly
mitochondrial transcription
rRNA methylation
rRNA modification
rRNA binding
mitochondrial RNA metabolic process
mitochondrial large ribosomal subunit
protein targeting to mitochondrion
ribosome assembly
establishment of protein localization to mitochondrion
protein localization to mitochondrion
RNA methylation
double-stranded DNA binding
mitochondrial translation
mitochondrial gene expression
RNA modification
rRNA processing
mitochondrial transport
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
macromolecule methylation
ribosome biogenesis
methylation
camera-type eye development
protein targeting
eye development
visual system development
sensory system development
mitochondrial matrix
translation
ncRNA processing
peptide biosynthetic process
establishment of protein localization to organelle
mitochondrion organization
ribonucleoprotein complex biogenesis
ncRNA metabolic process
heart development
amide biosynthetic process
peptide metabolic process