MTF1 [The Human Chemical-Genetic Interaction Map Project]

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======= MTF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTF1
  * **<color #00a2e8>Official Name</color>**: metal regulatory transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4520|4520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14872|Q14872]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600172|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). {ECO:0000269|PubMed:8065932}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone acetyltransferase binding|
|proximal promoter sequence-specific DNA binding|
|response to cadmium ion|
|transcription coactivator activity|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to metal ion|
|response to oxidative stress|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to inorganic substance|
|DNA-binding transcription factor activity|
|central nervous system development|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-3|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.68|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.53|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.23|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.22|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.89|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.87|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.79|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.71|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.71|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.73|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.76|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.83|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.94|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.01|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.11|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.11|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.11|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.12|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.16|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.3|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.43|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.44|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.83|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.99|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dot1l|DOT1L]]|0.472|
|[[:human genes:e:eif3k|EIF3K]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1193
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTF1 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>