MTF1

Entrez Summary: N/A
UniProt Summary: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). {ECO:0000269|PubMed:8065932}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK2206 4μM R08 exp504	-3
GSK-J4 1μM R07 exp362	-2.68
GSK-J4 1-1.25μM to day4 R07 exp363	-2.53
Cadmium 60μM R08 exp462	-2.23
WYE-354 6μM R02 exp90	-2.22
MS023 7μM R03 exp135	-1.89
UM0129480 7μM R02 exp85	-1.87
Trimetrexate 0.03μM R08 exp535	-1.79
Lead acetate 990μM R08 exp496	1.71
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.71
Losmapimod 1μM R07 exp376	1.73
Cidofovir 10μM R07 exp345	1.76
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.83
A-196 10μM R03 exp114	1.94
HMS-I1 1μM R01 exp46	2.01
Dynasore 10μM R04 exp180	2.11
ML-792 0.2μM R08 exp505	2.11
TRAIL 50ng/ml R00 exp36	2.11
THZ531 0.11μM R07 exp409	2.12
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.16
THZ531 0.225μM R08 exp444	2.3
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.43
MLN-4924 0.2μM R00 exp21	2.44
TRAIL 5ng/ml R00 exp35	2.73
Aminopterin 0.005μM R07 exp335	2.83
Resminostat 0.5μM R07 exp393	2.99
Tubacin 1.6μM R07 exp416	3.63

Global Fraction of Cell Lines Where Essential: 5/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/15
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
DOT1L	0.472
EIF3K	0.409

histone acetyltransferase binding
proximal promoter sequence-specific DNA binding
response to cadmium ion
transcription coactivator activity
RNA polymerase II regulatory region sequence-specific DNA binding
response to metal ion
response to oxidative stress
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
response to inorganic substance
DNA-binding transcription factor activity
central nervous system development
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process