MTFR1

Entrez Summary: This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009].
UniProt Summary: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dinaciclib 0.007μM R07 exp355	-2.03
HMS-I2 10μM R06 exp288	-1.94
L-BMAA 500 to 750μM on day4 R04 exp185	-1.78
Dimethyloxaloylglycine 11μM R07 exp314	1.7
MKC9989 10μM R03 exp133	1.71
Cannabidiol 20μM R08 exp466	1.9

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial fission
aerobic respiration
cellular respiration
energy derivation by oxidation of organic compounds
organelle fission
generation of precursor metabolites and energy
mitochondrion organization
oxidation-reduction process
mitochondrion