MTHFD1 [The Human Chemical-Genetic Interaction Map Project]

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======= MTHFD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTHFD1
  * **<color #00a2e8>Official Name</color>**: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4522|4522]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11586|P11586]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTHFD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTHFD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|THF DHG CYH C|
|THF DHG CYH|
|FTHFS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity|
|histidine biosynthetic process|
|formate-tetrahydrofolate ligase activity|
|10-formyltetrahydrofolate biosynthetic process|
|methylenetetrahydrofolate dehydrogenase (NAD+) activity|
|methenyltetrahydrofolate cyclohydrolase activity|
|aromatic amino acid family biosynthetic process|
|methylenetetrahydrofolate dehydrogenase (NADP+) activity|
|10-formyltetrahydrofolate metabolic process|
|embryonic neurocranium morphogenesis|
|tetrahydrofolate biosynthetic process|
|embryonic viscerocranium morphogenesis|
|histidine metabolic process|
|folic acid-containing compound biosynthetic process|
|tetrahydrofolate interconversion|
|purine nucleobase biosynthetic process|
|imidazole-containing compound metabolic process|
|methionine biosynthetic process|
|dicarboxylic acid biosynthetic process|
|pteridine-containing compound biosynthetic process|
|methionine metabolic process|
|serine family amino acid biosynthetic process|
|sulfur amino acid biosynthetic process|
|tetrahydrofolate metabolic process|
|folic acid metabolic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|aspartate family amino acid biosynthetic process|
|one-carbon metabolic process|
|folic acid-containing compound metabolic process|
|pteridine-containing compound metabolic process|
|aromatic amino acid family metabolic process|
|sulfur amino acid metabolic process|
|serine family amino acid metabolic process|
|nucleobase metabolic process|
|embryonic cranial skeleton morphogenesis|
|cellular modified amino acid biosynthetic process|
|pigment biosynthetic process|
|aspartate family amino acid metabolic process|
|pigment metabolic process|
|alpha-amino acid biosynthetic process|
|cranial skeletal system development|
|cellular amino acid biosynthetic process|
|somite development|
|water-soluble vitamin metabolic process|
|neural tube closure|
|tube closure|
|embryonic skeletal system morphogenesis|
|dicarboxylic acid metabolic process|
|primary neural tube formation|
|neural tube formation|
|embryonic epithelial tube formation|
|vitamin metabolic process|
|embryonic skeletal system development|
|epithelial tube formation|
|coenzyme biosynthetic process|
|morphogenesis of embryonic epithelium|
|tube formation|
|purine nucleotide biosynthetic process|
|neural tube development|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|skeletal system morphogenesis|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|embryonic organ morphogenesis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|epithelial tube morphogenesis|
|cellular amino acid metabolic process|
|purine nucleotide metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|morphogenesis of an epithelium|
|embryonic organ development|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|skeletal system development|
|drug metabolic process|
|heart development|
|amide biosynthetic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|small molecule biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cellular amide metabolic process|
|tube development|
|circulatory system development|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|embryo development|
|oxoacid metabolic process|
|organic acid metabolic process|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.23|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.13|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.06|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.02|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.98|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.81|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.8|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.77|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.7|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.71|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.71|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.81|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.85|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.89|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.89|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.12|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.15|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.16|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.19|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gart|GART]]|0.494|
|[[:human genes:a:atic|ATIC]]|0.473|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 182
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTHFD1 Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>