MTMR1

Entrez Summary: This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate. {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Ibrutinib 10μM R08 exp442	1.75
Asunaprenir 3μM R07 exp336	2.09

GRAM
Myotub-related

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
regulation of phosphatidylinositol dephosphorylation
phosphatidylinositol-3-phosphatase activity
phosphatidylinositol dephosphorylation
phospholipid dephosphorylation
regulation of phospholipid metabolic process
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
phosphatidylinositol biosynthetic process
phosphatidylinositol metabolic process
lipid modification
glycerophospholipid biosynthetic process
regulation of dephosphorylation
protein dephosphorylation
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
dephosphorylation
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
protein homodimerization activity
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process