MTMR9 [The Human Chemical-Genetic Interaction Map Project]

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======= MTMR9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTMR9
  * **<color #00a2e8>Official Name</color>**: myotubularin related protein 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=66036|66036]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QG7|Q96QG7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTMR9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTMR9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential). {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myotub-related|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of phosphatidylinositol dephosphorylation|
|enzyme regulator activity|
|positive regulation of phosphatase activity|
|positive regulation of dephosphorylation|
|negative regulation of autophagy|
|regulation of phospholipid metabolic process|
|protein phosphatase binding|
|ruffle membrane|
|phosphatidylinositol biosynthetic process|
|phosphatidylinositol metabolic process|
|regulation of phosphatase activity|
|protein stabilization|
|glycerophospholipid biosynthetic process|
|regulation of dephosphorylation|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|negative regulation of cellular catabolic process|
|regulation of protein stability|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|regulation of autophagy|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|organophosphate biosynthetic process|
|endocytosis|
|lipid biosynthetic process|
|protein-containing complex|
|import into cell|
|perinuclear region of cytoplasm|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|regulation of catabolic process|
|endoplasmic reticulum|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.87|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.72|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.79|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.91|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.92|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mtmr6|MTMR6]]|0.53|
|[[:human genes:c:cog7|COG7]]|0.431|
|[[:human genes:r:rab1b|RAB1B]]|0.43|
|[[:human genes:a:arpc4|ARPC4]]|0.419|
|[[:human genes:c:commd5|COMMD5]]|0.412|
|[[:human genes:a:actr3|ACTR3]]|0.406|
|[[:human genes:u:unc50|UNC50]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3453
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTMR9 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>