MTPN

Entrez Summary: N/A
UniProt Summary: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269|PubMed:10329199, ECO:0000269|PubMed:16895918, ECO:0000269|PubMed:20625546}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank 2
Ank

regulation of barbed-end actin filament capping
cerebellar granular layer formation
cerebellar granule cell differentiation
F-actin capping protein complex
cerebellar granular layer morphogenesis
cerebellar granular layer development
cell differentiation in hindbrain
cerebellar cortex formation
cerebellar cortex morphogenesis
positive regulation of cardiac muscle hypertrophy
positive regulation of muscle hypertrophy
skeletal muscle tissue regeneration
cerebellum morphogenesis
hindbrain morphogenesis
catechol-containing compound metabolic process
catecholamine metabolic process
cerebellar cortex development
regulation of actin filament depolymerization
regulation of cardiac muscle hypertrophy
regulation of muscle hypertrophy
tissue regeneration
cellular response to mechanical stimulus
regulation of protein depolymerization
phenol-containing compound metabolic process
regulation of muscle adaptation
cerebellum development
metencephalon development
regulation of protein complex disassembly
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
hindbrain development
positive regulation of NF-kappaB transcription factor activity
regeneration
positive regulation of cell growth
regulation of actin filament polymerization
central nervous system neuron differentiation
regulation of cell size
regulation of actin polymerization or depolymerization
regulation of actin filament length