MTR [The Human Chemical-Genetic Interaction Map Project]

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======= MTR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTR
  * **<color #00a2e8>Official Name</color>**: 5-methyltetrahydrofolate-homocysteine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4548|4548]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99707|Q99707]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Met synt B12|
|Pterin bind|
|B12-binding|
|S-methyl trans|
|B12-binding 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methionine synthase activity|
|cobalamin binding|
|methionine biosynthetic process|
|cellular response to nitric oxide|
|methionine metabolic process|
|sulfur amino acid biosynthetic process|
|cellular response to reactive nitrogen species|
|response to nitric oxide|
|cobalamin metabolic process|
|axon regeneration|
|aspartate family amino acid biosynthetic process|
|neuron projection regeneration|
|pteridine-containing compound metabolic process|
|sulfur amino acid metabolic process|
|response to axon injury|
|response to bronchodilator|
|aspartate family amino acid metabolic process|
|tetrapyrrole metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|water-soluble vitamin metabolic process|
|vitamin metabolic process|
|cellular response to reactive oxygen species|
|regeneration|
|sulfur compound biosynthetic process|
|response to reactive oxygen species|
|alpha-amino acid metabolic process|
|cellular response to inorganic substance|
|cellular response to oxidative stress|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|methylation|
|sulfur compound metabolic process|
|response to oxidative stress|
|cellular response to drug|
|axon development|
|cofactor metabolic process|
|drug metabolic process|
|response to inorganic substance|
|response to wounding|
|small molecule biosynthetic process|
|cellular response to nitrogen compound|
|neuron projection development|
|neuron development|
|zinc ion binding|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|neuron differentiation|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|cellular response to stress|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-3.21|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.3|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.98|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.88|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.77|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.94|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.34|
|[[:results:exp211|AICAR 240μM R05 exp211]]|4.96|
|[[:results:exp116|AICAR 240μM R03 exp116]]|7.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mtrr|MTRR]]|0.622|
|[[:human genes:m:mmachc|MMACHC]]|0.586|
|[[:human genes:m:mthfd1l|MTHFD1L]]|0.567|
|[[:human genes:s:slc25a32|SLC25A32]]|0.538|
|[[:human genes:m:mthfd2|MTHFD2]]|0.518|
|[[:human genes:n:nudt2|NUDT2]]|0.516|
|[[:human genes:a:ak2|AK2]]|0.477|
|[[:human genes:s:shmt2|SHMT2]]|0.458|
|[[:human genes:a:adk|ADK]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8737
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTR Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>