MTR

Entrez Summary: This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
UniProt Summary: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

methionine synthase activity
cobalamin binding
methionine biosynthetic process
cellular response to nitric oxide
methionine metabolic process
sulfur amino acid biosynthetic process
cellular response to reactive nitrogen species
response to nitric oxide
cobalamin metabolic process
axon regeneration
aspartate family amino acid biosynthetic process
neuron projection regeneration
pteridine-containing compound metabolic process
sulfur amino acid metabolic process
response to axon injury
response to bronchodilator
aspartate family amino acid metabolic process
tetrapyrrole metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
water-soluble vitamin metabolic process
vitamin metabolic process
cellular response to reactive oxygen species
regeneration
sulfur compound biosynthetic process
response to reactive oxygen species
alpha-amino acid metabolic process
cellular response to inorganic substance
cellular response to oxidative stress
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
methylation
sulfur compound metabolic process
response to oxidative stress
cellular response to drug
axon development
cofactor metabolic process
drug metabolic process
response to inorganic substance