MUC6 [The Human Chemical-Genetic Interaction Map Project]

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======= MUC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MUC6
  * **<color #00a2e8>Official Name</color>**: mucin 6, oligomeric mucus/gel-forming
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4588|4588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6W4X9|Q6W4X9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MUC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MUC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/158374|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIL|
|VWD|
|C8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of gastrointestinal epithelium|
|epithelial structure maintenance|
|O-glycan processing|
|digestive system process|
|Golgi lumen|
|protein O-linked glycosylation|
|stimulatory C-type lectin receptor signaling pathway|
|digestion|
|innate immune response activating cell surface receptor signaling pathway|
|extracellular matrix structural constituent|
|tissue homeostasis|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|glycoprotein metabolic process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|activation of immune response|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|carbohydrate derivative metabolic process|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|homeostatic process|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.09|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.05|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9012
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MUC6 Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>