MUC6

Entrez Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016].
UniProt Summary: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. {ECO:0000269|PubMed:10209489, ECO:0000269|PubMed:10330458, ECO:0000269|PubMed:11988092}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

maintenance of gastrointestinal epithelium
epithelial structure maintenance
O-glycan processing
digestive system process
Golgi lumen
protein O-linked glycosylation
stimulatory C-type lectin receptor signaling pathway
digestion
innate immune response activating cell surface receptor signaling pathway
extracellular matrix structural constituent
tissue homeostasis
innate immune response-activating signal transduction
activation of innate immune response
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
multicellular organismal homeostasis
anatomical structure homeostasis
positive regulation of innate immune response
positive regulation of response to biotic stimulus
glycoprotein metabolic process
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
carbohydrate derivative biosynthetic process
activation of immune response
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
carbohydrate derivative metabolic process
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process