MVB12A

Entrez Summary: N/A
UniProt Summary: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

virus maturation
endosome to lysosome transport via multivesicular body sorting pathway
ESCRT I complex
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
endosome transport via multivesicular body sorting pathway
viral budding
receptor catabolic process
multivesicular body assembly
multivesicular body organization
multivesicular body sorting pathway
virion assembly
endosome to lysosome transport
intracellular transport of virus
host cell
transport of virus
multi-organism transport
multi-organism localization
endosome organization
ubiquitin binding
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
receptor metabolic process
lysosomal transport
late endosome membrane
SH3 domain binding
vesicle
vacuolar transport
lipid binding
macroautophagy
viral life cycle
endosome membrane
endosomal transport
autophagy
process utilizing autophagic mechanism
vesicle organization
endomembrane system organization
centrosome
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process