MVK

Entrez Summary: This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: May be a regulatory site in cholesterol biosynthetic pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-2.68
Cryptotanshinone 12μM R05 exp227	-2.36
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.06
THZ531 0.225μM R08 exp444	-1.92
Isoniazid 100μM R08 exp494	-1.8
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.74

Global Fraction of Cell Lines Where Essential: 583/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	26/28
blood	27/28
bone	18/26
breast	24/33
central nervous system	27/56
cervix	3/4
colorectal	13/17
esophagus	8/13
fibroblast	1/1
gastric	16/16
kidney	19/21
liver	11/20
lung	60/75
lymphocyte	14/16
ovary	19/26
pancreas	22/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	0/1
skin	21/24
soft tissue	9/9
thyroid	1/2
upper aerodigestive	14/22
urinary tract	19/29
uterus	2/5

Expression Distribution

mevalonate kinase activity
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isopentenyl diphosphate metabolic process
isopentenyl diphosphate biosynthetic process
isoprenoid biosynthetic process
acetyl-CoA metabolic process
cholesterol biosynthetic process
regulation of cholesterol biosynthetic process
secondary alcohol biosynthetic process
regulation of sterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
acyl-CoA metabolic process
thioester metabolic process
peroxisome
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
ribonucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
sterol metabolic process
negative regulation of inflammatory response
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
negative regulation of defense response
magnesium ion binding
phospholipid biosynthetic process
coenzyme metabolic process
steroid metabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process