MX1

Entrez Summary: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dynamin family protein polymerization involved in membrane fission
dynamin family protein polymerization involved in mitochondrial fission
membrane fission
mitochondrial fission
negative regulation of viral genome replication
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
negative regulation of viral life cycle
protein polymerization
regulation of viral genome replication
negative regulation of viral process
mitochondrial membrane
membrane fusion
regulation of viral life cycle
defense response to virus
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
nuclear membrane
microtubule binding
response to virus
organelle fission
GTPase activity
GTP binding
mitochondrion organization
cytokine-mediated signaling pathway
perinuclear region of cytoplasm
innate immune response
regulation of multi-organism process
cellular protein-containing complex assembly
membrane organization
apoptotic process
endoplasmic reticulum membrane
defense response to other organism
cellular response to cytokine stimulus
programmed cell death
identical protein binding
cell death
immune effector process