MX2

Entrez Summary: N/A
UniProt Summary: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dynamin family protein polymerization involved in mitochondrial fission
dynamin family protein polymerization involved in membrane fission
membrane fission
mitochondrial fission
response to interferon-alpha
cellular response to type I interferon
type I interferon signaling pathway
nuclear pore
response to type I interferon
protein polymerization
mitochondrial membrane
regulation of nucleocytoplasmic transport
membrane fusion
mRNA transport
RNA transport
defense response to virus
nucleic acid transport
establishment of RNA localization
RNA localization
microtubule binding
nucleobase-containing compound transport
response to virus
organelle fission
GTPase activity
regulation of intracellular transport
GTP binding
mitochondrion organization
cytokine-mediated signaling pathway
innate immune response
cellular protein-containing complex assembly
membrane organization
regulation of cellular localization
defense response to other organism
cellular response to cytokine stimulus
immune effector process
response to cytokine
regulation of cell cycle
response to other organism
response to external biotic stimulus
response to biotic stimulus