MYD88

Gene Information

Official Symbol: MYD88
Official Name: MYD88 innate immune signal transduction adaptor
Aliases and Previous Symbols: N/A
Entrez ID: 4615
UniProt: Q99836
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5109
Expression level (log2 read counts): 6.45

Expression Distribution

Death
TIR

TIR domain binding
positive regulation of interleukin-23 production
Toll signaling pathway
Toll-like receptor binding
regulation of interleukin-23 production
cellular response to oxidised low-density lipoprotein particle stimulus
death receptor binding
toll-like receptor 9 signaling pathway
positive regulation of interleukin-17 production
positive regulation of cytokine production involved in inflammatory response
3-UTR-mediated mRNA stabilization
response to lipoprotein particle
cellular response to lipoprotein particle stimulus
regulation of interleukin-17 production
MyD88-dependent toll-like receptor signaling pathway
regulation of cytokine production involved in inflammatory response
mRNA stabilization
RNA stabilization
positive regulation of interleukin-8 production
negative regulation of mRNA catabolic process
protein self-association
negative regulation of RNA catabolic process
cellular response to type I interferon
type I interferon signaling pathway
regulation of interleukin-8 production
response to type I interferon
positive regulation of type I interferon production
negative regulation of mRNA metabolic process
cellular response to mechanical stimulus
defense response to Gram-positive bacterium
positive regulation of interleukin-6 production
interleukin-1-mediated signaling pathway
toll-like receptor signaling pathway
regulation of type I interferon production
pattern recognition receptor signaling pathway
positive regulation of inflammatory response
regulation of interleukin-6 production
positive regulation of NF-kappaB transcription factor activity
cellular response to interleukin-1
regulation of mRNA stability