MYF5

Gene Information

Official Symbol: MYF5
Official Name: myogenic factor 5
Aliases and Previous Symbols: N/A
Entrez ID: 4617
UniProt: P13349
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6079
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
BI-6727 0.04μM R03 exp98	-1.74
Lapatinib 5μM R01 exp47	1.81

HLH
Basic
Myf5

positive regulation of skeletal muscle fiber development
regulation of skeletal muscle fiber development
muscle cell fate commitment
positive regulation of myoblast fusion
cartilage condensation
cell aggregation
regulation of myoblast fusion
positive regulation of myoblast differentiation
positive regulation of skeletal muscle tissue development
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
positive regulation of myotube differentiation
regulation of skeletal muscle tissue development
skeletal muscle cell differentiation
E-box binding
regulation of myoblast differentiation
regulation of myotube differentiation
positive regulation of striated muscle cell differentiation
somitogenesis
positive regulation of muscle organ development
positive regulation of striated muscle tissue development
positive regulation of muscle tissue development
RNA polymerase II transcription factor complex
muscle tissue morphogenesis
somite development
positive regulation of muscle cell differentiation
muscle organ morphogenesis
embryonic skeletal system morphogenesis
segmentation
regulation of striated muscle cell differentiation
regulation of cell-matrix adhesion
skeletal muscle tissue development
embryonic skeletal system development
regulation of striated muscle tissue development
skeletal muscle organ development
regulation of muscle tissue development
regulation of muscle organ development
regulation of muscle cell differentiation
cartilage development
regulation of cell-substrate adhesion