MYF6

Gene Information

Official Symbol: MYF6
Official Name: myogenic factor 6
Aliases and Previous Symbols: N/A
Entrez ID: 4618
UniProt: P23409
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010].
UniProt Summary: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8651
Expression level (log2 read counts): -7.68

Expression Distribution

HLH
Basic

positive regulation of skeletal muscle fiber development
regulation of skeletal muscle fiber development
muscle cell fate commitment
positive regulation of myoblast fusion
regulation of myoblast fusion
positive regulation of myoblast differentiation
positive regulation of skeletal muscle tissue development
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
positive regulation of myotube differentiation
skeletal muscle tissue regeneration
regulation of skeletal muscle tissue development
E-box binding
skeletal muscle cell differentiation
regulation of myoblast differentiation
regulation of myotube differentiation
positive regulation of striated muscle cell differentiation
tissue regeneration
somitogenesis
positive regulation of striated muscle tissue development
positive regulation of muscle organ development
positive regulation of muscle tissue development
RNA polymerase II transcription factor complex
muscle tissue morphogenesis
somite development
muscle organ morphogenesis
positive regulation of muscle cell differentiation
segmentation
regulation of striated muscle cell differentiation
skeletal muscle tissue development
regulation of striated muscle tissue development
skeletal muscle organ development
regulation of muscle tissue development
regulation of muscle organ development
regulation of muscle cell differentiation
regeneration
anterior/posterior pattern specification
muscle cell differentiation
cell fate commitment
striated muscle tissue development