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Ask your administrator if you think this is wrong. ======= MYH2 ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: MYH2 * **<color #00a2e8>Official Name</color>**: myosin heavy chain 2 * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4620|4620]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKX2|Q9UKX2]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH2&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH2|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160740|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]. * **<color #00a2e8>UniProt Summary</color>**: Muscle contraction. Required for cytoskeleton organization (By similarity). {ECO:0000250}. <button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> |Myosin tail 1| |Myosin head| |Myosin N| </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |muscle myosin complex| |myosin filament| |microfilament motor activity| |myofibril| |muscle filament sliding| |actin-myosin filament sliding| |sarcomere| |actin-mediated cell contraction| |actin filament-based movement| |Fc-gamma receptor signaling pathway involved in phagocytosis| |immune response-regulating cell surface receptor signaling pathway involved in phagocytosis| |Fc receptor mediated stimulatory signaling pathway| |Fc-gamma receptor signaling pathway| |calmodulin binding| |actin filament binding| |Fc receptor signaling pathway| |muscle contraction| |muscle system process| |phagocytosis| |immune response-activating cell surface receptor signaling pathway| |immune response-regulating cell surface receptor signaling pathway| |immune response-activating signal transduction| |actin filament-based process| |immune response-regulating signaling pathway| |protein-containing complex| |activation of immune response| |positive regulation of immune response| |immune effector process| |regulation of immune response| |positive regulation of immune system process| |ATP binding| |movement of cell or subcellular component| |regulation of immune system process| |vesicle-mediated transport| |system process| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.74| |[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.81| |[[:results:exp115|A-366 10μM R03 exp115]]|1.7| |[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.7| |[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.72| |[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.72| |[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.82| |[[:results:exp11|CCCP 1μM R00 exp11]]|1.87| |[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.98| |[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.99| |[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.02| |[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.04| |[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.14| |[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.3| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:t:tfip11|TFIP11]]|0.489| |[[:human genes:t:tbc1d3g|TBC1D3G]]|0.486| |[[:human genes:c:cbwd3|CBWD3]]|0.472| |[[:human genes:c:c14orf93|C14orf93]]|0.471| |[[:human genes:z:znf106|ZNF106]]|0.464| |[[:human genes:u:ubap1|UBAP1]]|0.462| |[[:human genes:t:tbc1d3h|TBC1D3H]]|0.462| |[[:human genes:s:stil|STIL]]|0.461| |[[:human genes:c:cbwd5|CBWD5]]|0.453| |[[:human genes:c:cdca3|CDCA3]]|0.452| |[[:human genes:t:tbc1d3c|TBC1D3C]]|0.451| |[[:human genes:v:vasn|VASN]]|0.448| |[[:human genes:r:rbbp5|RBBP5]]|0.444| |[[:human genes:r:rrp15|RRP15]]|0.44| |[[:human genes:p:psmc1|PSMC1]]|0.439| |[[:human genes:p:psmd3|PSMD3]]|0.434| |[[:human genes:p:plk4|PLK4]]|0.434| |[[:human genes:r:rad51|RAD51]]|0.433| |[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.432| |[[:human genes:t:tbc1d3f|TBC1D3F]]|0.431| |[[:human genes:n:nol12|NOL12]]|0.429| |[[:human genes:s:sf3a1|SF3A1]]|0.428| |[[:human genes:t:ticrr|TICRR]]|0.428| |[[:human genes:c:cope|COPE]]|0.427| |[[:human genes:n:npipb5|NPIPB5]]|0.426| |[[:human genes:c:cbwd6|CBWD6]]|0.426| |[[:human genes:m:myo1h|MYO1H]]|0.425| |[[:human genes:p:psmb4|PSMB4]]|0.421| |[[:human genes:w:wdr87|WDR87]]|0.419| |[[:human genes:t:tbc1d3|TBC1D3]]|0.418| |[[:human genes:m:mt1e|MT1E]]|0.417| |[[:human genes:s:syt9|SYT9]]|0.416| |[[:human genes:g:gosr2|GOSR2]]|0.415| |[[:human genes:r:rfxank|RFXANK]]|0.413| |[[:human genes:r:rps19bp1|RPS19BP1]]|0.411| |[[:human genes:d:ddtl|DDTL]]|0.41| |[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.409| |[[:human genes:r:rbm39|RBM39]]|0.407| |[[:human genes:t:tbc1d3i|TBC1D3I]]|0.405| |[[:human genes:t:tbc1d3e|TBC1D3E]]|0.404| |[[:human genes:s:supt5h|SUPT5H]]|0.404| |[[:human genes:t:tbc1d3k|TBC1D3K]]|0.403| |[[:human genes:t:tbc1d3l|TBC1D3L]]|0.403| |[[:human genes:c:ciapin1|CIAPIN1]]|0.402| |[[:human genes:p:psmb3|PSMB3]]|0.402| |[[:human genes:s:supt6h|SUPT6H]]|0.401| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: 0/739 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|0/1| |909776.0|0/1| |bile duct|0/28| |blood|0/28| |bone|0/26| |breast|0/33| |central nervous system|0/56| |cervix|0/4| |colorectal|0/17| |esophagus|0/13| |fibroblast|0/1| |gastric|0/16| |kidney|0/21| |liver|0/20| |lung|0/75| |lymphocyte|0/16| |ovary|0/26| |pancreas|0/24| |peripheral nervous system|0/16| |plasma cell|0/15| |prostate|0/1| |skin|0/24| |soft tissue|0/9| |thyroid|0/2| |upper aerodigestive|0/22| |urinary tract|0/29| |uterus|0/5| </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 1904 * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='MYH2 Expression in NALM6 Cells: -2.69'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2026/01/07 22:36by 127.0.0.1