MYH2
Gene Information
- Official Symbol: MYH2
- Official Name: myosin heavy chain 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4620
- UniProt: Q9UKX2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009].
- UniProt Summary: Muscle contraction. Required for cytoskeleton organization (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1904
- Expression level (log2 read counts): -2.69
MYH2 Expression in NALM6 Cells: -2.69
