MYO10

Entrez Summary: N/A
UniProt Summary: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plus-end directed microfilament motor activity
actin-dependent ATPase activity
filopodium membrane
filopodium tip
spectrin binding
myosin complex
phosphatidylinositol-3,4,5-trisphosphate binding
regulation of filopodium assembly
ruffle
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
cell cortex
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
regulation of cell shape
cytoskeleton-dependent intracellular transport
lamellipodium
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
calmodulin binding
actin filament binding
Fc receptor signaling pathway
positive regulation of cell-cell adhesion
neuron projection
phagocytosis
neuronal cell body
regulation of cell-cell adhesion
positive regulation of cell adhesion
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
regulation of cell morphogenesis
immune response-activating signal transduction
immune response-regulating signaling pathway
activation of immune response
regulation of cell adhesion
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
nucleolus
positive regulation of immune response
regulation of cellular component biogenesis