MYO1A [The Human Chemical-Genetic Interaction Map Project]

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======= MYO1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO1A
  * **<color #00a2e8>Official Name</color>**: myosin IA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4640|4640]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBC5|Q9UBC5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601478|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in directing the movement of organelles along actin filaments. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin TH1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microvillus assembly|
|microvillus organization|
|plasma membrane raft|
|filamentous actin|
|myosin complex|
|basal plasma membrane|
|motor activity|
|brush border|
|cortical actin cytoskeleton|
|lateral plasma membrane|
|microvillus|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|vesicle localization|
|basolateral plasma membrane|
|calmodulin binding|
|actin filament binding|
|apical plasma membrane|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organelle localization|
|sensory perception|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|ATP binding|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.85|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.81|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.76|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.9|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.92|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.97|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO1A Expression in NALM6 Cells: -1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>