MYOZ1 [The Human Chemical-Genetic Interaction Map Project]

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======= MYOZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYOZ1
  * **<color #00a2e8>Official Name</color>**: myozenin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58529|58529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP98|Q9NP98]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYOZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYOZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605603|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calsarcin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of skeletal muscle tissue regeneration|
|skeletal muscle fiber adaptation|
|FATZ binding|
|telethonin binding|
|regulation of skeletal muscle tissue regeneration|
|protein serine/threonine phosphatase inhibitor activity|
|skeletal muscle adaptation|
|negative regulation of calcineurin-mediated signaling|
|negative regulation of calcineurin-NFAT signaling cascade|
|pseudopodium|
|striated muscle adaptation|
|negative regulation of calcium-mediated signaling|
|muscle adaptation|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|sarcomere organization|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|myofibril assembly|
|negative regulation of wound healing|
|negative regulation of response to wounding|
|regulation of calcium-mediated signaling|
|cellular component assembly involved in morphogenesis|
|negative regulation of developmental growth|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|actomyosin structure organization|
|regulation of phosphoprotein phosphatase activity|
|skeletal muscle tissue development|
|Z disc|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of wound healing|
|regulation of protein dephosphorylation|
|muscle cell development|
|regulation of response to wounding|
|regulation of phosphatase activity|
|striated muscle cell differentiation|
|regulation of dephosphorylation|
|actin cytoskeleton|
|negative regulation of growth|
|muscle cell differentiation|
|actin binding|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|regulation of developmental growth|
|negative regulation of response to external stimulus|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of protein modification process|
|regulation of growth|
|organelle assembly|
|negative regulation of catalytic activity|
|cellular component morphogenesis|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|cell development|
|negative regulation of gene expression|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.72|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.72|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYOZ1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>