MYOZ1

Entrez Summary: The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012].
UniProt Summary: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of skeletal muscle tissue regeneration
skeletal muscle fiber adaptation
FATZ binding
telethonin binding
regulation of skeletal muscle tissue regeneration
protein serine/threonine phosphatase inhibitor activity
skeletal muscle adaptation
negative regulation of calcineurin-mediated signaling
negative regulation of calcineurin-NFAT signaling cascade
pseudopodium
striated muscle adaptation
negative regulation of calcium-mediated signaling
muscle adaptation
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
sarcomere organization
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
myofibril assembly
negative regulation of wound healing
negative regulation of response to wounding
regulation of calcium-mediated signaling
cellular component assembly involved in morphogenesis
negative regulation of developmental growth
negative regulation of phosphatase activity
negative regulation of dephosphorylation
actomyosin structure organization
regulation of phosphoprotein phosphatase activity
skeletal muscle tissue development
Z disc
skeletal muscle organ development
striated muscle cell development
regulation of wound healing
regulation of protein dephosphorylation
muscle cell development
regulation of response to wounding
regulation of phosphatase activity
striated muscle cell differentiation
regulation of dephosphorylation
actin cytoskeleton