MYOZ2

Entrez Summary: The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011].
UniProt Summary: Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

skeletal muscle fiber adaptation
FATZ binding
protein phosphatase 2B binding
telethonin binding
skeletal muscle adaptation
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of calcineurin-mediated signaling
striated muscle adaptation
negative regulation of calcium-mediated signaling
muscle adaptation
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
sarcomere organization
sarcomere
myofibril assembly
regulation of calcium-mediated signaling
cellular component assembly involved in morphogenesis
actomyosin structure organization
skeletal muscle tissue development
Z disc
skeletal muscle organ development
striated muscle cell development
muscle cell development
striated muscle cell differentiation
actin cytoskeleton
muscle cell differentiation
actin binding
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
negative regulation of intracellular signal transduction
actin filament-based process
organelle assembly
cellular component morphogenesis
negative regulation of transcription by RNA polymerase II
anatomical structure formation involved in morphogenesis