MYSM1 [The Human Chemical-Genetic Interaction Map Project]

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======= MYSM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYSM1
  * **<color #00a2e8>Official Name</color>**: Myb like, SWIRM and MPN domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114803|114803]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VVJ2|Q5VVJ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYSM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYSM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612176|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. {ECO:0000269|PubMed:17707232}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-binding|
|Mov34|
|SWIRM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|monoubiquitinated histone deubiquitination|
|monoubiquitinated histone H2A deubiquitination|
|monoubiquitinated protein deubiquitination|
|regulation of hair follicle development|
|histone deubiquitination|
|regulation of hair cycle|
|thiol-dependent ubiquitinyl hydrolase activity|
|metallopeptidase activity|
|regulation of epidermis development|
|pigmentation|
|thiol-dependent ubiquitin-specific protease activity|
|histone binding|
|chromatin remodeling|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|histone modification|
|covalent chromatin modification|
|regulation of hemopoiesis|
|protein-containing complex|
|chromatin organization|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|chromosome organization|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.69|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.7|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.73|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.74|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.74|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.8|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.81|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.02|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.09|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tada2a|TADA2A]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10550
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYSM1 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>