MYSM1

Entrez Summary: N/A
UniProt Summary: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. {ECO:0000269|PubMed:17707232}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monoubiquitinated histone deubiquitination
monoubiquitinated histone H2A deubiquitination
monoubiquitinated protein deubiquitination
regulation of hair follicle development
histone deubiquitination
regulation of hair cycle
thiol-dependent ubiquitinyl hydrolase activity
metallopeptidase activity
regulation of epidermis development
pigmentation
thiol-dependent ubiquitin-specific protease activity
histone binding
chromatin remodeling
protein deubiquitination
transcription coactivator activity
protein modification by small protein removal
histone modification
covalent chromatin modification
regulation of hemopoiesis
protein-containing complex
chromatin organization
regulation of cell migration
regulation of cell motility
regulation of locomotion
protein modification by small protein conjugation or removal
regulation of cellular component movement
chromosome organization
positive regulation of transcription by RNA polymerase II
proteolysis
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression