N4BP2L2

Gene Information

Official Symbol: N4BP2L2
Official Name: NEDD4 binding protein 2 like 2
Aliases and Previous Symbols: N/A
Entrez ID: 10443
UniProt: Q92802
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12650
Expression level (log2 read counts): 7.36

Expression Distribution

negative regulation of hematopoietic stem cell differentiation
positive regulation of hematopoietic stem cell proliferation
regulation of hematopoietic stem cell proliferation
negative regulation of hematopoietic progenitor cell differentiation
negative regulation of stem cell differentiation
positive regulation of stem cell proliferation
transcriptional repressor complex
regulation of stem cell proliferation
regulation of hematopoietic stem cell differentiation
regulation of hematopoietic progenitor cell differentiation
regulation of stem cell differentiation
negative regulation of hemopoiesis
positive regulation of hemopoiesis
transcription corepressor activity
enzyme binding
negative regulation of immune system process
regulation of hemopoiesis
negative regulation of cell differentiation
molecular function
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
negative regulation of developmental process
positive regulation of immune system process
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
regulation of cell population proliferation
regulation of immune system process
negative regulation of gene expression
positive regulation of multicellular organismal process
regulation of cell differentiation