NAA20 [The Human Chemical-Genetic Interaction Map Project]

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======= NAA20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA20
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 20, NatB catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51126|51126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61599|P61599]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAA20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAA20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610833|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. {ECO:0000269|PubMed:18570629}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FR47|
|Acetyltransf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NatB complex|
|N-terminal peptidyl-methionine acetylation|
|peptide alpha-N-acetyltransferase activity|
|peptidyl-methionine modification|
|N-terminal protein amino acid acetylation|
|N-terminal protein amino acid modification|
|intracellular|
|protein acetylation|
|protein acylation|
|protein maturation|
|peptidyl-amino acid modification|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.99|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.98|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.91|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.9|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.89|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.8|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.79|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.78|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.76|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.72|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.7|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:adsl|ADSL]]|0.451|
|[[:human genes:v:vezt|VEZT]]|0.437|
|[[:human genes:p:ppp4c|PPP4C]]|0.432|
|[[:human genes:t:thg1l|THG1L]]|0.432|
|[[:human genes:r:rpp21|RPP21]]|0.428|
|[[:human genes:a:alg13|ALG13]]|0.427|
|[[:human genes:t:txnl4b|TXNL4B]]|0.424|
|[[:human genes:s:srp14|SRP14]]|0.424|
|[[:human genes:a:aars|AARS]]|0.423|
|[[:human genes:g:gemin6|GEMIN6]]|0.423|
|[[:human genes:e:eno1|ENO1]]|0.421|
|[[:human genes:f:fnta|FNTA]]|0.42|
|[[:human genes:g:gmppb|GMPPB]]|0.419|
|[[:human genes:a:alg1|ALG1]]|0.418|
|[[:human genes:r:rtcb|RTCB]]|0.418|
|[[:human genes:r:rpe|RPE]]|0.41|
|[[:human genes:d:ddx20|DDX20]]|0.407|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.405|
|[[:human genes:m:mapk14|MAPK14]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 57/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|2/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAA20 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>