NAA20

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. {ECO:0000269|PubMed:18570629}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	-1.99
Momordin-Ic 10μM R08 exp506	-1.98
Doxorubicin 0.02μM R08 exp478	-1.91
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.9
MSC2530818 10μM R07 exp379	-1.89
HMS-I1 1μM R01 exp46	-1.8
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.79
Adefovir 20μM R07 exp332	-1.78
Apcin 50 to 100μM on day4 R04 exp176	-1.76
Taxol 0.004μM R03 exp103	-1.72
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.7
2-Deoxy-D-glucose 800μM R05 exp214	1.94

Global Fraction of Cell Lines Where Essential: 57/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	2/26
breast	4/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	3/16
ovary	2/26
pancreas	4/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	0/5

Expression Distribution

FR47
Acetyltransf 1

NatB complex
N-terminal peptidyl-methionine acetylation
peptide alpha-N-acetyltransferase activity
peptidyl-methionine modification
N-terminal protein amino acid acetylation
N-terminal protein amino acid modification
intracellular
protein acetylation
protein acylation
protein maturation
peptidyl-amino acid modification
gene expression