NAA60 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NAA60 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA60
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 60, NatF catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79903|79903]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7X0|Q9H7X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAA60&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAA60|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614246|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). {ECO:0000269|PubMed:21750686, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000305|PubMed:21981917}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acetyltransf 1|
|FR47|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-terminal peptidyl-methionine acetylation|
|H4 histone acetyltransferase activity|
|peptide alpha-N-acetyltransferase activity|
|peptidyl-methionine modification|
|N-terminal protein amino acid acetylation|
|N-terminal protein amino acid modification|
|histone H3 acetylation|
|histone H4 acetylation|
|histone acetylation|
|nucleosome assembly|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|chromatin assembly|
|protein acetylation|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein acylation|
|protein-DNA complex assembly|
|protein maturation|
|protein-DNA complex subunit organization|
|chromosome segregation|
|DNA conformation change|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|cell population proliferation|
|Golgi membrane|
|chromatin organization|
|cellular protein-containing complex assembly|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|chromosome organization|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-3.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.94|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.74|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.19|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.1|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.99|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.95|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.87|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.79|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.78|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.7|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.7|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.71|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.71|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.16|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.22|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|5.45|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|8.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc19a1|SLC19A1]]|0.463|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8676
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAA60 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>