NAA60

Entrez Summary: This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015].
UniProt Summary: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). {ECO:0000269|PubMed:21750686, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000305|PubMed:21981917}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-3.86
LB-100 2μM R05 exp210	-2.94
Colchicine 0.009μM R05 exp215	-2.74
BML-284 0.09μM R08 exp460	-2.19
UM131593 0.2μM R03 exp106	-2.1
Demecolcine 0.03μM R05 exp228	-1.99
LB-100 4.1μM R02 exp72	-1.95
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.87
Radicicol 0.16μM R05 exp242	-1.79
Brefeldin A 0.02μM R00 exp8	-1.78
Docetaxel 0.002μM R01 exp45	-1.71
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.7
Apcin 25μM plus proTAME 2μM R04 exp177	1.7
AICAR 240μM R03 exp116	1.71
Adefovir 20μM R07 exp332	1.71
Momordin-Ic 10μM R08 exp506	2.16
CR131-b 0.005μM R08 exp474	2.22
Methotrexate 0.01μM R08 exp501	5.45
Aminopterin 0.005μM R07 exp335	8.49

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Acetyltransf 1
FR47

N-terminal peptidyl-methionine acetylation
H4 histone acetyltransferase activity
peptide alpha-N-acetyltransferase activity
peptidyl-methionine modification
N-terminal protein amino acid acetylation
N-terminal protein amino acid modification
histone H3 acetylation
histone H4 acetylation
histone acetylation
nucleosome assembly
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
chromatin assembly
protein acetylation
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein acylation
protein-DNA complex assembly
protein maturation
protein-DNA complex subunit organization
chromosome segregation
DNA conformation change
peptidyl-lysine modification
histone modification
covalent chromatin modification
cell population proliferation
Golgi membrane
chromatin organization
cellular protein-containing complex assembly
protein homodimerization activity
peptidyl-amino acid modification
chromosome organization
protein-containing complex assembly
protein-containing complex subunit organization
gene expression