NAPRT1

Entrez Summary: N/A
UniProt Summary: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. {ECO:0000269|PubMed:17604275}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NAD salvage
nicotinate nucleotide biosynthetic process
nicotinate nucleotide metabolic process
pyridine nucleotide salvage
nicotinate nucleotide salvage
nicotinate phosphoribosyltransferase activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity
NAD biosynthesis via nicotinamide riboside salvage pathway
nucleotide salvage
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
cellular metabolic compound salvage
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
azurophil granule lumen
coenzyme biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
response to oxidative stress
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
myeloid leukocyte activation
leukocyte activation involved in immune response