NBL1

Gene Information

Official Symbol: NBL1
Official Name: NBL1, DAN family BMP antagonist
Aliases and Previous Symbols: N/A
Entrez ID: 4681
UniProt: P41271
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7416
Expression level (log2 read counts): -4.27

Expression Distribution

Cys knot
DAN

sequestering of BMP from receptor via BMP binding
sequestering of BMP in extracellular matrix
determination of dorsal identity
negative regulation of monocyte chemotaxis
determination of dorsal/ventral asymmetry
maintenance of protein location in extracellular region
morphogen activity
negative regulation of mononuclear cell migration
sequestering of extracellular ligand from receptor
extracellular negative regulation of signal transduction
BMP binding
extracellular regulation of signal transduction
negative regulation of leukocyte chemotaxis
regulation of monocyte chemotaxis
negative regulation of leukocyte migration
regulation of mononuclear cell migration
negative regulation of BMP signaling pathway
negative regulation of chemotaxis
dorsal/ventral pattern formation
regulation of BMP signaling pathway
maintenance of protein location
regulation of leukocyte chemotaxis
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
determination of bilateral symmetry
specification of symmetry
negative regulation of cellular response to growth factor stimulus
maintenance of location
protein localization to extracellular region
regulation of leukocyte migration
regulation of chemotaxis
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell migration
regulation of cellular response to growth factor stimulus
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regionalization
negative regulation of response to external stimulus
positive regulation of neuron differentiation
pattern specification process