NCAPD3 [The Human Chemical-Genetic Interaction Map Project]

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======= NCAPD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCAPD3
  * **<color #00a2e8>Official Name</color>**: non-SMC condensin II complex subunit D3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23310|23310]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42695|P42695]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCAPD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCAPD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609276|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cnd1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear condensin complex|
|meiotic chromosome condensation|
|condensed chromosome, centromeric region|
|nuclear pericentric heterochromatin|
|mitotic chromosome condensation|
|chromosome separation|
|chromosome condensation|
|methylated histone binding|
|chromosome organization involved in meiotic cell cycle|
|mitotic sister chromatid segregation|
|histone binding|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic cell cycle process|
|DNA packaging|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|chromatin binding|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.21|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.02|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.12|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.25|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 537/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|20/28|
|bone|18/25|
|breast|25/33|
|central nervous system|44/56|
|cervix|2/4|
|colorectal|11/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|11/15|
|kidney|18/21|
|liver|15/20|
|lung|61/75|
|lymphocyte|8/14|
|ovary|20/26|
|pancreas|16/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1970
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCAPD3 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>