NCAPD3

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 537/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	20/28
bone	18/25
breast	25/33
central nervous system	44/56
cervix	2/4
colorectal	11/17
esophagus	10/13
fibroblast	1/1
gastric	11/15
kidney	18/21
liver	15/20
lung	61/75
lymphocyte	8/14
ovary	20/26
pancreas	16/24
peripheral nervous system	14/16
plasma cell	11/15
prostate	0/1
skin	23/24
soft tissue	4/7
thyroid	1/2
upper aerodigestive	15/22
urinary tract	17/29
uterus	2/5

Expression Distribution

nuclear condensin complex
meiotic chromosome condensation
condensed chromosome, centromeric region
nuclear pericentric heterochromatin
mitotic chromosome condensation
chromosome separation
chromosome condensation
methylated histone binding
chromosome organization involved in meiotic cell cycle
mitotic sister chromatid segregation
histone binding
sister chromatid segregation
mitotic nuclear division
meiotic cell cycle process
DNA packaging
nuclear chromosome segregation
meiotic cell cycle
chromosome segregation
nuclear division
DNA conformation change
organelle fission
chromatin binding
cell division
mitotic cell cycle process
mitotic cell cycle
cell cycle process
chromosome organization
cell cycle
reproductive process
reproduction
membrane